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Isopure Protein Powder Drink Mix
Photo: Open Food Facts contributors (CC BY-SA)

Protein powders

Isopure Protein Powder Drink Mix

30.5 g

Excellent out of 100 High confidence
  • Contains non-nutritive sweeteners
  • Contains artificial flavors
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Why it scores 91

Isopure Protein Powder Drink Mix scores 91 out of 100 (Excellent) under GoodSwap’s published rules. What moved the score most:

  1. Sucralose: In a 2022 randomized study, sucralose and saccharin altered the gut microbiome and impaired glucose responses in some people; a 2023 lab study raised questions about its by-product sucralose-6-acetate. Strong
  2. Whey protein concentrate / isolate: An ingredient typical of ultra-processed foods (NOVA group 4). Info
  3. Calcium phosphate: EFSA (2019) set a group ADI for phosphates of 40 mg/kg body weight (as phosphorus) and noted that infants, toddlers and children may exceed it. Strong

Every line of the math is on The Receipt below, with its evidence tier and sources.

The Receipt

Protein Powder Drink Mix

START100

Ingredients

  • Sucralose
    Strong In a 2022 randomized study, sucralose and saccharin altered the gut microbiome and impaired glucose responses in some people; a 2023 lab study raised questions about its by-product sucralose-6-acetate. [1][2][3][4][5]
  • Whey protein concentrate / isolate
    Info An ingredient typical of ultra-processed foods (NOVA group 4). [6]
  • Calcium phosphate
    Strong EFSA (2019) set a group ADI for phosphates of 40 mg/kg body weight (as phosphorus) and noted that infants, toddlers and children may exceed it. [7]
  • Silicon dioxide
    Info An additive class typical of ultra-processed foods (NOVA group 4). [6]
  • Soy lecithin
    Info An additive class typical of ultra-processed foods (NOVA group 4). [6]
  • Natural flavors
    Info "Natural flavor" is a legal category (21 CFR 101.22(a)(3)): flavor substances from spices, fruits, vegetables, meat, dairy or fermentation. [8][6]
  • Artificial flavors
    Strong US dietary guidelines advise limiting foods with artificial flavors. [5][9]
  • Xanthan gum
    Info An ingredient class typical of ultra-processed foods (NOVA group 4). [6]
subtotal−9.5
TOTAL 91Excellent

100 − 9.5 = 90.5 → 91

GTIN 00089094026219 · 2026-03-07

score v1.3.0 · kb 2026.10.11

High confidence

Same product, same score. Every time.

Nutrition per 100 g

Energy361 kcal
Fat1.6 g
Saturated fat0 g
Carbohydrates0 g
Sugars0 g
Added sugars0 g
Fiber0 g
Protein82 g
Salt1.6 g

Serving: 30.5g

Ingredients

High Moderate Not recognized Tap an ingredient for its evidence and rules.
Label text, as published

Whey Protein Isolate, Calcium Phosphate, Magnesium Oxide, Ascorbic Acid, Niacinamide, d-alpha Tocopheryl Acetate, Zinc Oxide, Biotin, Calcium D-Pantothenate, Vitamin A Acetate, Potassium Iodide, Silicon Dioxide, Chromium Chloride, Copper Sulfate, Pyridoxine Hydrochloride, Riboflavin, Sodium Molybdate, Sodium Selenite, Manganese Sulfate, Thiamine Mononitrate, Folic Acid, Phytonadione, Cyanocobalamin, Soy Lecithin, Natural Flavor, Artificial Flavor, Salt, Sucralose, Xanthan Gum.

Allergens and diets

Contains: Milk, Soy

  • Not vegan
  • Palm-oil-free

Always check the package: recipes change.

Healthiest protein powders in the US

More from Isopure

Sources

  1. Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance

    Cell · September 2022 · Peer-reviewed

    “As groups, each administered NNS distinctly altered stool and oral microbiome and plasma metabolome, whereas saccharin and sucralose significantly impaired glycemic responses.”

    doi.org

  2. Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: in vitro screening assays

    Journal of Toxicology and Environmental Health, Part B · Aug 18, 2023 · Peer-reviewed

    “Sucralose-6-acetate significantly increased the expression of genes associated with inflammation, oxidative stress, and cancer”

    doi.org

  3. EFSA finds sucralose safe when used as currently authorised; cannot confirm safety of extending its use

    European Food Safety Authority · Feb 17, 2026 · Agency assessment

    “EFSA’s experts concluded that the sweetener sucralose (E 955) continues to be safe for consumers for its currently authorised uses as a food additive.”

    efsa.europa.eu

  4. WHO advises not to use non-sugar sweeteners for weight control in newly released guideline

    World Health Organization · May 15, 2023 · Agency assessment

    “The recommendation is based on the findings of a systematic review of the available evidence which suggests that use of NSS does not confer any long-term benefit in reducing body fat in adults or children.”

    who.int

  5. Dietary Guidelines for Americans, 2025–2030

    U.S. Department of Health and Human Services and U.S. Department of Agriculture · January 2026 · Regulator

    “Limit foods and beverages that include artificial flavors, petroleum-based dyes, artificial preservatives, and low-calorie non-nutritive sweeteners.”

    cdn.realfood.gov

  6. Ultra-processed foods: what they are and how to identify them

    Public Health Nutrition · April 2019 · Peer-reviewed

    doi.org

  7. EFSA issues new advice on phosphates

    European Food Safety Authority · Jun 12, 2019 · Agency assessment

    “We estimated that dietary exposure to phosphates may exceed the new ADI for infants, toddlers and children with average consumption of phosphates in their diet.”

    efsa.europa.eu

  8. 21 CFR 101.22 Foods; labeling of spices, flavorings, colorings and chemical preservatives

    Electronic Code of Federal Regulations (eCFR), U.S. Office of the Federal Register · Dec 19, 2016 · Law

    “whose significant function in food is flavoring rather than nutritional.”

    ecfr.gov

  9. 21 CFR 172.515 Synthetic flavoring substances and adjuvants

    Electronic Code of Federal Regulations (eCFR), U.S. Office of the Federal Register · Oct 9, 2017 · Law

    ecfr.gov